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Rong Wen Selected Research

Ciliary Neurotrophic Factor (CNTF)

10/2015Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia.
9/2014CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function.
1/2014Protection of pattern electroretinogram and retinal ganglion cells by oncostatin M after optic nerve injury.
3/2010CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration.
4/2007Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina.
10/2002Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa.
4/2002Levobetaxolol-induced Up-regulation of retinal bFGF and CNTF mRNAs and preservation of retinal function against a photic-induced retinopathy.

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Rong Wen Research Topics

Disease

9Retinal Degeneration
01/2014 - 04/2002
8Retinitis Pigmentosa (Pigmentary Retinopathy)
02/2015 - 10/2002
5Neoplasms (Cancer)
01/2020 - 01/2003
5Choroidal Neovascularization
05/2017 - 01/2006
3Color Vision Defects (Color Blindness)
10/2015 - 06/2013
3Glaucoma
01/2014 - 04/2002
2Inflammation (Inflammations)
04/2022 - 11/2010
2Retinal Neovascularization
12/2021 - 01/2014
2Pathologic Neovascularization
05/2017 - 03/2008
2Infections
08/2015 - 06/2014
2Macular Degeneration (Age-Related Maculopathy)
02/2015 - 06/2008
1Cholangiocarcinoma
09/2022
1COVID-19
05/2022
1Glioblastoma (Glioblastoma Multiforme)
03/2022
1Dystonia (Limb Dystonia)
02/2022
1Meige Syndrome
02/2022
1Blindness (Hysterical Blindness)
12/2021
1Retinopathy of Prematurity (Retrolental Fibroplasia)
12/2021
1Renal Cell Carcinoma (Grawitz Tumor)
09/2021
1Neoplasm Metastasis (Metastasis)
09/2021
1Hemorrhage
01/2021
1Hematoma
01/2021
1Hypoxia (Hypoxemia)
01/2018
1Stomach Neoplasms (Stomach Cancer)
11/2015
1Photophobia (Light Sensitivity)
09/2014
1Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders)
09/2014
1Mitochondrial Diseases (Mitochondrial Disease)
06/2014
1Virus Diseases (Viral Diseases)
06/2014
1Diabetic Retinopathy (Retinopathy, Diabetic)
01/2014
1Optic Nerve Injuries
01/2014
1Inborn Genetic Diseases (Disease, Hereditary)
06/2013
1Channelopathies
06/2013
1Ischemia
01/2012
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2011
1Sarcoma (Soft Tissue Sarcoma)
12/2010
1Carcinoma (Carcinomatosis)
12/2010
1Fibrosis (Cirrhosis)
11/2010
1Insulin Resistance
02/2010
1Iron Overload
06/2008
1Hypertrophy
06/2008
1Hyperplasia
06/2008

Drug/Important Bio-Agent (IBA)

7Ciliary Neurotrophic Factor (CNTF)IBA
10/2015 - 04/2002
6Retinaldehyde (Retinal)IBA
12/2021 - 04/2003
3RNA (Ribonucleic Acid)IBA
01/2020 - 12/2010
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2018 - 11/2010
3Proteins (Proteins, Gene)FDA Link
10/2015 - 08/2004
3dehydrodolicholIBA
01/2014 - 12/2013
3Diphosphates (Pyrophosphates)IBA
01/2014 - 12/2013
3matrigelIBA
11/2010 - 01/2006
2Biomarkers (Surrogate Marker)IBA
02/2015 - 12/2013
2DolicholsIBA
09/2014 - 12/2013
2CytokinesIBA
01/2014 - 03/2011
2Oncostatin MIBA
01/2014 - 03/2011
2LigandsIBA
11/2010 - 03/2008
2Ceruloplasmin (Ferroxidase)IBA
06/2008 - 04/2003
2Neuroprotective AgentsIBA
04/2007 - 10/2005
1Tumor Biomarkers (Tumor Markers)IBA
09/2022
1CreatinineIBA
05/2022
1Indicators and Reagents (Reagents)IBA
04/2022
1Levetiracetam (Keppra)FDA LinkGeneric
03/2022
1Temozolomide (Temodar)FDA LinkGeneric
03/2022
1Pharmaceutical PreparationsIBA
02/2022
1Angiogenesis Inducing Agents (Angiogenesis Factor)IBA
12/2021
1Monoclonal AntibodiesIBA
12/2021
1secretogranin IIIIBA
12/2021
1SDMIBA
09/2021
1Adenosine Diphosphate (ADP)IBA
01/2021
1Hemoglobins (Hemoglobin)IBA
01/2021
1MicroRNAs (MicroRNA)IBA
01/2020
1Metformin (Glucophage)FDA LinkGeneric
05/2017
1ElementsIBA
11/2016
1MucinsIBA
11/2015
1Small Interfering RNA (siRNA)IBA
08/2015
1Rhodopsin (Visual Purple)IBA
02/2015
1cis-prenyl transferaseIBA
09/2014
1CholesterolIBA
09/2014
1Adenosine Triphosphate (ATP)IBA
06/2014
1Antiviral Agents (Antivirals)IBA
06/2014
1Oxygen (Dioxygen)IBA
01/2014
1NucleotidesIBA
01/2014
1Nerve Growth Factors (Neurotrophins)IBA
01/2014
1Cyclic NucleotidesIBA
06/2013
1Interleukin-6 (Interleukin 6)IBA
03/2011
1Matrix Metalloproteinases (MMPs)IBA
12/2010
1Peptide Hydrolases (Proteases)FDA Link
12/2010
1Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA
12/2010
1afliberceptIBA
11/2010
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
11/2010
1Insulin (Novolin)FDA Link
02/2010
1LipofuscinIBA
06/2008
1IronIBA
06/2008
1A-factor (Streptomyces)IBA
06/2008
1AngiopoietinsIBA
03/2008
1TIE-2 Receptor (Receptor, TIE 2)IBA
03/2008

Therapy/Procedure

1Drug Therapy (Chemotherapy)
03/2022
1Deep Brain Stimulation
02/2022
1Radiotherapy
01/2020
1Therapeutics
05/2017
1Radiofrequency Ablation
11/2016
1Lasers (Laser)
12/2010